Services

Particle Identification

Our Particle Identification Platform utilizes the advanced HOUND Raman spectrometer, supported by an extensive standard spectrum database. This cutting-edge technology enables the rapid identification of a wide range of particles, including silicone oil, cellulose, proteins, fatty acids, and polymers, typically within 1 to 2 days. This capability provides robust support for particle tracing and product quality assurance.

Advanced Analytical Capabilities

Rapid Identification: Using HOUND equipped with 532 nm or 785 nm lasers, we scan particles from samples and collect their Raman spectra.
Database Matching: The collected spectra are matched against our comprehensive standard database to confirm particle identities through score matching.

Key Features of Our Particle Identification Services

Visible Particle Analysis: We specialize in identifying visible particles to support product release and stability studies.
Comprehensive Particle Library: Our library encompasses a broad range of raw materials and process-related production materials, ensuring accurate and detailed particle identification.

Client Recognition and Commitment

The professionalism and efficiency of our particle identification services have earned us significant recognition from our clients. We remain committed to continuously improving and optimizing our platform to meet evolving client needs and ensure exceptional service quality.

Video of Our Particle Identification Platform

You can copy the link and paste it into the browser to watch the video of our particle identification platform.

https://www.youtube.com/watch?v=JMtzcfL3HJo

Particle Identification Workflow

Visible particles are observed by visual inspection:
Particles are moved on filter rounds:
Particles can be identified by score matching with the Raman database:

Case Study

Cellulose: Particle approximately 2 mm was identified during the visual inspection of a specific sample. After filtering and analyzing the sample, data matching and comparison with standard spectra indicated that the particle is cellulose. Below are images of the particle and the corresponding spectrum.
IgG: A translucent particle was identified during the visual inspection of a specific sample. After filtering and analyzing the sample, data matching and comparison with standard spectra indicated that the particle is protein. Below are images of the particle and the corresponding spectrum.
Fatty Acid: A large number of fine particles were identified during the visual inspection of a specific sample. After filtering and analyzing the sample, data matching and comparison with standard spectra indicated that the particles are fatty acid, which may result from the degradation of the surfactant polysorbate 80 in the formulation. Below are images of the particles and the corresponding spectrum.
Polyethylene Low Density: Fine particles were identified during the visual inspection of a specific sample. After filtering and analyzing the sample, data matching and comparison with standard spectra indicated that the particles are low-density polyethylene. Below are images of the particles and the corresponding spectrum.
Silicon Oil: Fine particles were identified during the visual inspection of a specific sample. After filtering and analyzing the sample, data matching and comparison with standard spectra indicated that the particles are silicone oil, which may result from the syringe. Below are images of the particles and the corresponding spectrum.